True Launch Bar — provides taskbands with module-driven icons, such as the moon phase (using my horribly inaccurate Photographic skin), multi-clipboard, window list, RSS status etc. Coupled with UltraMon, my XP work PC has two dedicated taskbars (one per display), a different Quick Launch taskband on each one, a nice clock on the secondary taskbar (turned off on the primary as I wanted it at the far right) and lots of goodies such as the multi-clipboard and a screenshot-to-disc button. (UltraMon does not appear to be suitable for Windows 7/8 though.)
WizMouse — one of many programs that makes the mouse wheel scroll the window under the cursor. I used to use Tordex Wheel (free with True Launch Bar) but the developer refused to remove the retarded icon that was stuck in the tray and did naff all.
JujuEdit — the most adorably twisted text editor. Aside from the bug where it mistakes some files as Chinese, it will open any file on your PC <= 2 GB instantaneously, as text (if recognised) or as editable hex, and syntax highlighting carries over into hex view. Editing is non-destructive. Syntax highlighting is customisable using a regular expression state machine. Sadly it's long abandoned, as the developer switched to Mac, though it still works mostly OK in Windows 8. Unicode support is limited: no font substitution and all APIs are ASCII, so you can't find or replace Unicode or use it in filenames. It's full of bugs and problems, but nothing else on the planet is just so simple, fast, clean, and ready for you come text or binary. No-one else could ever rewrite this without creating something slow, bloated and overblown. (I have my own copy I copy to new machines with a bad workaround for the broken system menu icon, hence the chunky icon.) I can't have a PC without JujuEdit installed.
Launchy was fun, but for some reason I never really got into it. AutoHotkey and Inkscape of course. foobar2000 is a bit pants but I really appreciate the near-native UI and I've settled with it. 7+ Taskbar Tweaker helps a bit. StrokeIt (seriously) for mouse gestures — having a 4+ button mouse helps there as some programs already use right-drag and systemwide gestures really need a mouse button that is never used for dragging.